The protective effects of Elettaria cardamomum essential oil extracted against Decadron induced on pancreatic tissues in rats (Rattus norvegicus)
Аннотация
Background. Decadron is used to treat a wide range of disorders and regulates various physiological systems in the body. Literature data indicate that the essential oils of E. cardamomum exhibit multiple biological effects, including antihypertensive, antioxidant, antimicrobial properties, and pancreatic tissue protection.
Purpose. This study aims to investigate the protective effects of E. cardamomum essential oils on body weight loss, hyperinsulinemia, hyperglycemia, and histopathological changes in the pancreas of rats induced by Decadron. Additionally, the chemical composition of the essential oils was characterized using GC-MS.
Methodology. Rats were divided into six groups (n=5): (1) control, (2) Decadron-induced diabetes (1 mg/kg, orally), (3) induced diabetes + low-dose E. cardamomum essential oil (50 mg/kg, orally), (4) induced diabetes + high-dose E. cardamomum essential oil (100 mg/kg, orally), and (5 & 6) two groups receiving essential oils alone (50 & 100 mg/kg, orally). Diabetes was induced by administering Decadron (1 mg/kg, orally) for 14 days. Body weight was measured, and histopathological examination of pancreatic tissues was performed.
Results. Decadron administration led to a decrease in body weight and an increase in glucose and insulin levels. Histopathological examination revealed hypertrophy of the islets of Langerhans, disintegration of pancreatic cells, and hemorrhage within pancreatic tissue. However, these pathological changes were mitigated by E. cardamomum essential oil treatment. GC-MS analysis identified 29 volatile compounds in the essential oils.
Conclusion. Our findings suggest that cardamom oil may serve as an adjuvant in reducing elevated serum insulin and blood glucose levels in Decadron-induced diabetes.
EDN: JTFJUD
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