Methods of experimental reproduction of heart failure
Abstract
Background. Cardiovascular diseases represent a significant medical and social problem, with heart failure being a common outcome. This condition contributes substantially to the rising rates of disability and mortality. That’s why the experimental models to develop new strategies and approaches for managing heart failure are widely used.
Purpose. To review Russian and international (English-language) literature that describes methods of experimentally modeling heart failure.
Materials and methods. The analysis was based on materials from electronic databases such as eLibrary, PubMed, and CyberLeninka.
Results. The literature outlines various methods for experimentally inducing heart failure, which can be classified into three groups: surgical, pharmacological, and chemogenetic. Surgical models are often based on occlusion of the left coronary artery in animals or creation of overload of the left ventricle by volume and resistance. Pharmacological models include administration of drugs having cardiotoxic effect. The chemogenetic model allows to reveal the biochemical aspects of myocardial damage in heart failure.
Conclusion. Each of these approaches has its own advantages and limitations. Nevertheless, the considered experimental models are widely used and contribute to a more complete study of the pathogenesis of heart failure that develops under the influence of various etiological factors.
EDN: OYDUPR
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References
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Janssen, P. M. L., & Elnakish, M. T. (2019). Modeling heart failure in animal models for novel drug discovery and development. Expert Opinion on Drug Discovery, 14(4), 355–363. https://doi.org/10.1080/17460441.2019.1582636.
Kerfourn, А., Lamia, B., Muir, J., & Letellier, C. (2016). A dynamical model for heart remodeling during the two phases of pulmonary arterial hypertension. EPJ Nonlinear Biomedical Physics, 4(1), 1–24. https://doi.org/10.1140/epjnbp/s40366-015-0028-y.
Miyagi, C., Miyamoto, T., Kuroda, T., Karimov, J. H., Starling, R. C., & Fukamachi, K. (2022). Large animal models of heart failure with preserved ejection fraction. Heart Failure Reviews, 27(2), 595–608. https://doi.org/10.1007/s10741-021-10184-9. EDN: https://elibrary.ru/FXZZBX
Geens, J. H., Trenson, S., Rega, F. R., Verbeken, E. K., & Meyns, B. P. (2009). Ovine models for chronic heart failure. The International Journal of Artificial Organs, 32(8), 496–506.
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Sorrentino, A., & Michel, T. (2020). Redox à la carte: novel chemogenetic models of heart failure. British Journal of Pharmacology, 177, 3162–3167. https://doi.org/10.1111/bph.15093. EDN: https://elibrary.ru/TVJJHX
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