INDIVIDUAL FEATURES OF THE RESPONSE OF THE HUMAN IMMUNITY SYSTEM TO A SHORT-TERM STAY IN AIRCOOLED TO -25°C
Abstract
The study of the influence of cold on the individual characteristics of the response of the human immune system is of great importance from the standpoint of ensuring the adaptive reactions of a person’s stay among extreme environmental factors.
Purpose of the study. To establish the individual characteristics of the response of the human immune system to a short-term stay in an air environment cooled to -25°C.
Materials and methods. A complex of immunological studies of the composition of the peripheral venous blood of the examined practically healthy volunteers (132 women and 40 men) living in the city of Arkhangelsk, aged from 21 to 50 years, was carried out. Blood was collected from the cubital vein on an empty stomach in the morning before and immediately after total cooling for 5 minutes at a temperature of –25°C.
Results. It was found that 14.53% of the examined people are sensitive to general cooling and have an initial high level of background activity of the immune system. These individuals reacted by decreasing the level of lymphocytes in the blood by 1.5-4.5 times due to all functional forms of lymphocytes and by increasing the concentration of ATP in lymphocytes. A decrease in the lymphocyte count in response to general cooling is associated with an increase in the concentration of pro-inflammatory IL-6 and cortisol without changes in the content of IL-1β, IL-4 and IL-10.
Conclusion. The effect of cold on the human body leads to a decrease in the number of lymphocytes in the venous blood in 14.53% of cases, which can be explained by a decrease in the blood flow velocity in the vascular bed and the transition of lymphocytes to the parietal pool, as well as, probably, by an increase in the production of TNF-α, under the influence of which there is a transendothelial migration of lymphocytes into the tissue.
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Gol’derova A.S., Zakharova F.A., Alekseev S.N Osobennosti nespetsificheskoy adaptivnoy reaktsii u bol’nykh s ostroy kholodovoy travmoy [Features of nonspecific adaptive response in patients with acute cold injury]. Yakutskiy meditsinskiy zhurnal, 2009, no. 1 (25), pp. 7-9.
Dobrodeeva L.K., Zhilina L.P. Immunologicheskaya reaktivnost’, sostoyanie zdorov’ya naseleniya Arkhangel’skoy oblasti [Immunological reactivity, health status of the population of the Arkhangelsk region]. Ekaterinburg: UrO RAN, 2004, 229 p.
Zubatkina O.V., Dobrodeeva L.K., Kruglov S.D. Izmenenie immunnykh pokazateley i urovnya ATF limfotsitov perifericheskoy krovi u severyan pri kratkovremennom kholodovom vozdeystvii na organizm [Changes in immune parameters and the level of ATP in peripheral blood lymphocytes in northerners with short-term cold exposure to the body]. Yakutskiy meditsinskiy zhurnal, 2020, no. 4 (72), pp. 90-93. https://doi.org/10.25789/YMJ.2020.72.22
Levanyuk A.I. Izmeneniya pokazateley immuniteta i parametra poryadka, otrazhayushchego otnositel’nuyu stepen’ khaotichnosti sistemy (E) posle vozdeystviya kholoda na organizm cheloveka [Changes in immunity indices and the order parameter reflecting the relative degree of chaos of the system (E) after exposure to cold on the human body]. Vestnik Ural’skoy meditsinskoy nauki, 2018, no. 2 (15), pp. 271-277. https://doi.org/10.22138/2500-0918-2018-15-2-271-277
Ovsyannikova T.O. Profilaktika gipotermii novorozhdennykh telyat [Prevention of hypothermia in newborn calves]. M., 2003, 22 p.
Ponomarev V.V. Adaptatsionnye reaktsii organizma telyat v rannem postnatal’nom periode na nepreryvnoe deystvie umerenno nizkikh temperatur [Adaptive reactions of the body of calves in the early postnatal period to the continuous action of moderately low temperatures]. Kazan’, 2002, 22 p.
Samodova A.V., Dobrodeeva L.K. Vzaimosvyaz’ soderzhaniya endotelina-1 i urovnya immunnoy reaktsii u lyudey na vozdeystvie kratkovremennogo okhlazhdeniya [The relationship between the content of endothelin-1 and the level of the immune response in humans to the effects of short-term cooling]. Vestnik Ural’skoy meditsinskoy akademicheskoy nauki, 2018, vol. 15, no. 2, pp. 299-308. https://doi.org/10.22138/2500-0918-2018-15-2-299-308
Totolyan A.A., Freydlin I.S. Kletki immunnoy sistemy [Cells of the immune system]. Spb.: Nauka, 2000, 231 p.
Khasnulin V.I. Vvedenie v polyarnuyu meditsinu [Introduction to polar medicine. Novosibirsk: Publishing house of the Siberian Branch of the Russian Academy of Medical Sciences]. Novosibirsk: Izd-vo SO RAMN, 1998, 337 p.
Tseluyko S.S., Dorovskikh V.A., Krasavina N.P. Morfofunktsional’naya kharakteristika soedinitel’noy tkani organov dykhaniya pri obshchem okhlazhdenii organizma [Morphofunctional characteristics of the connective tissue of the respiratory system with general cooling of the body]. Blagoveshchensk: Izd-vo AGMA, 2000, 256 p.
Dobrodeeva L.K., Samodova A.V., Balashova S.N. Cellular reactions in capillary and venous blood in northerners to a short-term period in a climatic chamber. Immunity, Inflammation and Disease, 2020, vol. 8, no. 3, pp. 408-414. https://doi.org/10.1002/iid3.322
Evans P., Bristow M., Hucklebridge F. et. al. Stress, arousal, Cortisol and secretory immunoglobulin A in students undergoing assessment. Brit. J. Clin. Psychol., 1994, vol. 33, no. 4, pp. 575. https://doi.org/10.1111/j.2044-8260.1994.tb01154.x
Ford W.L., Gowans J.L. The Traffic of Lymphocytes. Seminars Hemat., 1969, vol. 6, no. 1, pp. 67-83.
Freccero C., Wollmer P., Sundkvist G. et. al. The influence of wavelength and probe configuration on findings of a skin vasoconstriction test when using laser Doppler perfusion devices. Microvascular Research, 2006, vol. 71, no. 1, pp. 64–67. https://doi.org/10.1016/j.mvr.2005.11.002
Liu Na, Liu Juntian, Ji Yuanyuan et. al. C-reactive protein induces TNF-α secretion by p38 MAPK-TLR4 signal pathway in rat vascular smooth muscle cells. Inflammation, 2011, vol. 34, no. 4, pp. 283-290. https://doi.org/10.1007/s10753-010-9234-z
Nemeth E., Rivera S., Gabajan V. et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Inv., 2004, vol. 113, no. 9, pp. 1271–1276. https://doi.org/10.1172/jci20945
Meuret G., Fliedner T.M. Neutrophil and monocyte kinetics in a case of cyclic neutropenia. Blood, 1974, vol. 43, no. 4, pp. 565-574. https://doi.org/10.1182/blood.V43.4.565.565
Senaris R.M., Trujillo M.L., Navia B. et. al. IL-6 regulates the expression of hypothalamic neuropeptides involed in body weight in gender-dependent way. J. Neuroendocrinol., 2011, vol. 23, no. 8, pp. 675-686. https://doi.org/10.1111/j.1365-2826.2011.02158.x
Shing M., Ramos I., Asafu-Adijei D. et. al. Curcumin improves the therapeutic efficacy of Listeriaat-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1. Cancer Med., 2013, vol. 2, no. 4, pp. 571-582. https://doi.org/10.1002/cam4.94
Thorleifsson A., Wulf H.C. Emollients and the response of facial skin to a cold environment. Br. J. Dermatol., 2003, vol. 148, no. 6, pp. 1149-1152. https://doi.org/10.1046/j.1365-2133.2003.05264.x
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