ANTIBACTERIAL EFFECT OF IODIDE PLATINUM AND PALLADIUM COMPLEXES
Abstract
Background. Bacterial pathogens develop high resistance to antimicrobial agents. As a result, science is constantly searching for new antimicrobial agents. Complexes of platinum metals provide a antibacterial effect, which makes them a promising subject of further research.
Purpose. The research objective was to screen the antimicrobial properties of platinum and palladium iodide complexes.
Materials and methods. Previously synthesized complexes of platinum (II) and platinum (II), both mononuclear and bionuclear, were tested for antimicrobial activity. The complexes contained terminal and bridged iodide ligands. The test cultures included Pseudomonas putida, Bacillus subtilis and Aspergillus niger. The experiment involved the disk-diffusion method and the macro method of serial dilutions.
Results. All the complexes inhibited the metabolic growth of microorganisms to various degrees. The Pt+2 binuclear complexes-nonelectrolytes [(NH3)2Pt(μ-I)2PtCl2] was less active than the Pt+2 cationic binuclear complex [(NH3)2Pt(μ-I)2Pt(NH3)2]Cl2. The antimicrobial activity of Pt+2 binuclear complexes-nonelectrolytes was comparable to the Pt+2 mononuclear complex цис-Pt(NH3)2I2. The highest antibacterial activity belonged to the bionuclear complex of palladium [enPd(μ-I)2Pden]Cl2. This complex has more lability of ligand bonds with the complexing agent then platinum complexes. The minimum inhibitory concentration (MIC) was > 110 μmol.
Conclusion. The results depended on the composition and structure of the complex, the nature of the complexing atom, the number and charge of the coordination centers, and the thermodynamic stability and lability of ligand bonds with the complexing agent.
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