INVESTIGATION OF THE FUNGICIDAL ACTIVITY OF NEW DERIVATIVES OF 7-R-1,5-DINITRO-3,7- DIAZABICYCLO[3.3.1]NONAN-2-ONE
Abstract
ackground. The problem of finding new effective fungicides for agriculture remains an urgent task of modern agrochemistry. The problem is exacerbated by the fact that, on the one hand, over the years, there has been an ever wider spread of fungi-phytopathogens, due to the intensification of agricultural production, and, on the other hand, there is an increase in the resistance of pathogens of fungal diseases to the available fungicides. This study is devoted to the study of the fungicidal activity of new derivatives of 3,7-diazabicyclo[3.3.1]nonane – 7-R-1,5-dinitro-3,7-diazabicyclo[3.3.1]nonan-2-ones. It is known that 3,7-diazabicyclononane derivatives have versatile biological activity, including showing antibacterial and fungicidal action. Previously obtained 7-R-1,5-dinitro-3,7-diazabicyclo[3.3.1]nonan-2-ones were studied for the manifestation of fungicidal activity in vitro in relation to phytopathogenic fungi of various taxonomic classes, which are the main cause diseases of agricultural crops.
Purpose. To investigate the fungicidal activity of new derivatives of 7-R-1,5-dinitro-3,7-diazabicyclo[3.3.1]nonan-2-ones on various phytopathogenic fungi, causative agents of the main fungal diseases of agricultural plants.
Materials and methods. The synthesized compounds were tested in vitro for fungicidal activity against seven fungi-phytopathogens of various taxonomic classes: V. inaequalis is the causative agent of apple scab, F. moniliforme is the main cause of fusarium diseases of cereal crops, R. solani is the causative agent of rhizoctonia, F. oxysporum, B sorokiniana - cause root rot, S. sclerotiorum is the causative agent of white rot, and P. ostreatus is the causative agent of tree stem rot. To determine the radial growth of mycelium, the fungal cultures were inoculated in agar nutrient medium with the addition of the test substance. The effective concentration of the drug in the sample was 30 mg/l. The suppression of fungal mycelium growth was calculated as a percentage using the Abbott`s formula. Measurements were carried out on the 3rd day. Commercial fungicides were selected as a comparison standard from the list of drugs presented in the State Catalog of Pesticides and Agrochemicals permitted for use on the territory of the Russian Federation.
Results. Most of the studied substances exhibit fungicidal activity. Some compounds have a pronounced fungicidal activity comparable to Russian commercial fungicides.
Conclusion. Thus, when studying the fungicidal activity of new 3,7-diazabicyclo[3.3.1]nonanes (bispidines) – 7-R-1,5-dinitro-3,7-diazabicyclo[3.3.1]nonan-2-ones on various fungi-phytopathogens, it was shown that some of the obtained compounds have pronounced fungicidal activity and are promising for further testing.
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Copyright (c) 2021 Evgeniya V. Ivanova, Maria B. Nikishina, Anastasia V. Tretyakova, Loik G. Mukhtorov, Leonid V. Perelomov, Yuri M. Atroshchenko
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