ADVERSE FEATURES OF PATIENTS WITH BENIGN DYSTROPHIC DISEASES OF THE VULVA

Keywords: lichen sclerosus of the vulva, benign dystrophic diseases of the vulva, adherence to therapy, clinical and anamnestic observation, infections of the urogenital tract

Abstract

Aim – to present the results of clinical and anamnestic observation, microbiological study of the microflora of the urogenital tract of women with benign dystrophic diseases of the vulva (DVD).

Materials and methods. We examined 88 women with verified benign DVA aged 18 to 68 years. Using the clinical-anamestic method, social, household, medical factors that may be associated with the course and outcome of DVA were studied, and the spectrum of the most common pathogens was analyzed.

Results. In addition to a number of social, domestic and medical reasons that may have an impact on the occurrence and course of DZV, the authors found that among the examined patients, an average of 2.2 years passed from the moment of the first signs of the disease to the first visit, while according to the literature data, this indicator averages 1.7 years. It was also established that the most common pathogens in DVD were Ureaplasma urealyticum (33%), HPV type 16/18 (24%) and Candida albicans (61%), Gardnerella vaginalis (28%), Staphylococcus epidermidis (44%), which may indicate both their starting and aggravating role in the origin of dystrophy.

Conclusion. These studies show late seeking medical help among a significant part of the surveyed (50%), which is partly due to shyness due to the intimate nature of the disease (66%), as well as an inattentive attitude to pathology (47%). The most common microorganisms in dystrophic diseases of the genitals were Ureaplasma urealyticum (33%), HPV type 16/18 (24%) and Candida albicans (61%), Gardnerella vaginalis (28%), Staphylococcus epidermidis (44%).

Downloads

Download data is not yet available.

Author Biographies

Delya F. Porsokhonova, Republican Specialized Scientific and Practical Medical Center for Dermatovenereology and Cosmetology Ministry of Healthcare of the Republic of Uzbekistan

MD, PhD, DSc (Medicine), Professor (Full), Head of STD and Reproductive health disorders

Andrey I. Yakubovich, Irkutsk State Medical University

MD, PhD, DSc (Medicine), Professor (Full), Head of the Department of Dermatovenereology and Cosmetology

Sevara N. Rakhmatullaeva, Republican Specialized Scientific and Practical Medical Center for Dermatovenereology and Cosmetology Ministry of Healthcare of the Republic of Uzbekistan

 Basic Doctoral Student

Marianna L. Rosstalnaya, Republican Specialized Scientific and Practical Medical Center for Dermatovenereology and Cosmetology Ministry of Healthcare of the Republic of Uzbekistan

Junior Researcher of the Scientific Group for the Study of STIs and Reproductive Health

Alexey N. Kaliagin, Irkutsk State Medical University

MD, MBA, PhD, DSc (Medicine), Professor (Full), Head of the Department of Internal Medicine Propedeutics

References

Ashrafyan L.A., Kharchenko N.V., Kiselev V.I. et al. Rak vul’vy: etiopatogeneticheskaya kontseptsiya [Vulvar cancer: an etiopathogenetic concept]. M., 2006, 192 p.

Gubaydullina T.N. Kreativnaya khirurgiya i onkologiya, 2009, no. 1, pp. 23-25.

Zharov A.V., Kolesnikova E.V., Penzhoyan G.A. Kubanskiy nauchnyy meditsinskiy vestnik, 2018, vol. 25, no. 6, pp. 78-82. https://doi.org/10.25207/1608-6228-2018-25-6-78-82

Kononova I., Oboskalova T., Ivanova I. Vrach, 2009, no. 7, pp. 82–83.

Korzhevskaya E.V., Kravets O.A., Kuznetsov V.V., Khokhlova S.V. Ploskokletochnyy rak vul’vy: Klinicheskie rekomendatsii Minzdrava Rossii [Squamous cell carcinoma of the vulva: Clinical guidelines of the Russian Ministry of Health]. 2018, 26 p.

Porsokhonova D.F., Sadykov R.R., Yakubovich A.I., Mukhamedova M.R., Rakhmatullaeva S.N. Byulleten’ meditsinskoy nauki, 2017, no. 3, pp. 70-73. https://bmn.asmu.ru/wp-content/uploads/2018/10/372017.pdf

Solopova A.G., Tseloval’nikova E.V., Moskvicheva V.S. et al. Akusherstvo, ginekologiya i reproduktsiya, 2018, vol. 12, no. 4, pp. 52-61. https://doi.org/10.17749/2313-7347.2018.12.4.052-061

Cherenkov V.G. Onkologiya [Oncology]. 2017. 512 p.

Chulkova O.V., Novikova E.G., Sokolov V.V., Chulkova E.A. Prakticheskaya onkologiya, 2006, vol. 7, no. 4, pp. 197-204. https://practical-oncology.ru/articles/320.pdf

Yakubovich A.I., Ilyukhina E.Yu. Sovremennye problemy revmatologii, 2005, no. 2, pp. 155-158.

Balbinotti R.R., Grossi F.S., Perez A.V., et al. Nonablative radiofrequency in the treatment of refractory vulvar lichen sclerosus: A case series. JAAD Case Rep., 2021, vol. 17, pp. 122-125. https://doi.org/10.1016/j.jdcr.2021.09.028

Bleeker M.C., Visser P.J., Overbeek L.I., et al. Lichen sclerosus: incidence and risk of vulvar squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev., 2016, vol. 25 (8), pp. 1224-1230. https://doi.org/10.1158/1055-9965.EPI-16-0019

Guidozzi F. Lichen sclerosus of the vulva. Climacteric, 2021, vol. 24 (5), pp. 513-520. https://doi.org/10.1080/13697137.2021.1948004

Van der Meijden W.I., Boffa M.J., Ter Harmsel W.A., et al. European guideline for the management of vulval conditions. J. Eur. Acad. Dermatol. Venereol., 2017, vol. 31 (6), pp. 925-941. https://doi.org/10.1111/jdv.14096

Yeon J., Oakley A., Olsson A., et al. Vulval lichen sclerosus: An Australasian management consensus. Australas J Dermatol., 2021, vol. 62(3), pp. 292-299. https://doi.org/10.1111/ajd.13594

Abstract views: 377

Published
2022-02-28
How to Cite
Porsokhonova, D., Yakubovich, A., Rakhmatullaeva, S., Rosstalnaya, M., & Kaliagin, A. (2022). ADVERSE FEATURES OF PATIENTS WITH BENIGN DYSTROPHIC DISEASES OF THE VULVA. Siberian Journal of Life Sciences and Agriculture, 14(1), 323-335. https://doi.org/10.12731/2658-6649-2022-14-1-323-335
Section
Public Health and Preventive Medicine