METHODOLOGICAL ASPECTS OF INTERSPECIES EXTRAPOLATION OF EXPERIMENTAL DATA UNDER PULSED ACOUSTIC INFLUENCE ON BIOOBJECTS (REVIEW)
Abstract
Background. Despite a significant number of theoretical and experimental studies, the issue of determining the threshold levels of pulsed acoustic exposure, when exceeded, their negative effect on the morphofunctional state of a biological object begins to appear. Traditionally, in laboratory conditions, such estimates are obtained in experiments on animals, varying the parameters of exposure, followed by extrapolation of the results obtained to humans. However, the pathophysiological mechanisms of disturbances that develop in experimental animals as a result of impulse acoustic impacts have not been sufficiently studied in this context, and indicators of the state of the physiological systems of a biological object that are sensitive to acoustic impulses are not currently taken into account when determining their safe levels.
Purpose. The purpose of the work was to analyze the pathophysiological mechanisms of the development of biological effects of pulsed low-intensity acoustic exposure at different levels of the organization of a living system and to develop a methodological approach to obtaining a quantitative assessment and extrapolation of data on such exposure from animals to humans, taking into account the physical parameters of the acoustic factor and characteristics of the state of the experimental biological object.
Materials and methods. The selection and systematic review of the scientific literature on the topic of research by keywords in specialized bibliographic databases was carried out.
Results. The analysis and generalization of the existing theories about the pathophysiological mechanisms of the biological action of acoustic impulses at different levels of the organization of a living system have been carried out. An original hypothetical scheme for interpreting the effects of acoustic exposure in animals is proposed, which is suitable for obtaining threshold estimates of the levels of the adverse effect of the factor on clinical parameters in experimental animals, and vulnerable critical links in the regulation of external respiration in mammals that cause the damaging effect of acoustic vibrations are identified. A scientific and methodological approach to interspecies extrapolation of medical and biological effects of exposure to low-amplitude air pressure waves from animals to humans has been developed, taking into account the anatomical and physiological parameters of the respiratory system of experimental animals, as well as the informative characteristics of the acoustic pulse. An empirical model is proposed that makes it possible to predict the threshold levels of the conditional power of adverse acoustic effects in humans using data on the development of lung damage in experimental animals of various biological species, and the features of setting up such a model are formulated.
Conclusion. It has been substantiated that it is relevant to refine the proposed empirical model and develop a theoretical model for extrapolation of the initial experimental data on the threshold of safe acoustic exposure from animals to humans, taking into account the interspecific patterns of functioning of physiological systems of the body that are critical to the impact.
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Список литературы
Ахметзянов И.М., Гребеньков С.В., Ломов О.П. Шум и инфразвук. Гигиенические аспекты. СПб.: Бип, 2002. 100 с.
Бонитенко Е.Ю., Кашуро В.А., Башарин В.А. Вопросы моделирования в экспериментальной токсикологии и медицине. Биомодели нулевого порядка // Медицина труда и промышленная экология. 2022. Т. 62. № 11. С. 718-732. https://doi.org/10.31089/1026-9428-2022-62-11-718-732
Гавриш Н.Н., Грабский Ю.В., Панкратов В.В., Аминов А.М., Максимов С.Г., Кущёв Г.Г. Методический подход к прогнозу работоспособности специалистов-операторов в экстремальных условиях деятельности при применении фармакологических средств коррекции функционального состояния организма с учетом экстраполяции данных от животных к человеку // Авиакосмическая и экологическая медицина. 2016. Т. 50, № 3. С. 65-72.
Даренская Н.Г., Ушаков И.Б., Иванов И.В. Экстраполяция экспериментальных данных на человека: принципы, подходы, обоснование методов и их использование в физиологии и радиобиологии. М.-Воронеж: Истоки, 2004. 232 с.
Даренская Н.Г., Ушаков И.Б., Иванов И.В. От эксперимента на животных – к человеку: поиски и решения. Воронеж: Научная книга, 2010. 237 с.
Дворянчиков В.В., Кузнецов М.С., Логаткин С.М., Голованов А.Е. Оценка воздействия специального звукового сигнала на функциональное состояние органа слуха (экспериментальное исследование) // Медицинский совет. 2022. Т. 16. № 20. С. 16-21. https://doi.org/10.21518/2079-701X-2022-16-20-16-21
Драган С.П., Богомолов А.В. Метод оценивания акустической безопасности человека // Siberian Journal of Life Sciences and Agriculture. 2021. Т. 13. № 1. С. 259-278. https://doi.org/10.12731/2658-6649-2021-13-1-259-278
Драган С.П., Богомолов А.В., Кезик В.И. Анализ импедансных характеристик дыхательной системы животных и человека // Российский журнал биомеханики. 2020. Т. 24. № 2. С. 187-195. https://doi.org/10.15593/RZhBiomeh/2020.2.06
Драган С.П., Кезик В.И., Богомолов А.В. Физиологические аспекты импедансометрии легких // Известия Российской академии наук. Серия биологическая. 2022. № 2. С. 181-190. https://doi.org/10.31857/S1026347022010061
Зинкин В.Н., Шешегов П.М. Помеховое и маскирующее действие высокоинтенсивного шума и способы их снижения // Авиакосмическая и экологическая медицина. 2021. Т. 55. № 6. С. 5-12. https://doi.org/10.21687/0233-528X-2021-55-6-5-12
Иванов И.В., Ушаков И.Б. Основные подходы к экстраполяции данных с животных на человека в радиобиологическом эксперименте // Медицинская радиология и радиационная безопасность. 2020. Т. 65, № 3. С. 5-12.
Иванов Н.И., Зинкин В.Н., Сливина Л.П. Биомеханические механизмы действия низкочастотных акустических колебаний на человека // Российский журнал биомеханики. 2020. Т. 24. № 2. С. 216-231. https://doi.org/10.15593/RZhBiomeh/2020.2.09
Измеров Н.Ф., Суворов Г.А., Куралесин Н.А., Овакимов В.Г. Инфразвук как фактор риска здоровью человека (гигиенические, медико-биологические и патогенетические механизмы). Воронеж: Истоки, 1998. 275 с.
Каркищенко Н.Н. Через критерии подобия и аллометрии к валидации и экстраполяции в биомедицине // Биомедицина. 2007. № 1. С. 5-28.
Коваленко И.Ю., Степанов А.В., Селезнев А.Б., Сайфуллин Р.Ф., Пономарев Д.Б. Патогенетическое обоснование формирования соматической патологии при длительном воздействии низкочастотного шума // Вестник Российской Военно-медицинской академии. 2017. № 2 (58). С. 249-256.
Котеров А.Н., Ушенкова Л.Н., Зубенкова Э.С., Вайнсон А.А., Бирюков А.П. Соотношение возрастов основных лабораторных животных (мышей, крыс, хомячков и собак) и человека: актуальность для проблемы возрастной радиочувствительности и анализ опубликованных данных // Медицинская радиология и радиационная безопасность. 2018. Т. 63. № 1. С. 5-27. https://doi.org/10.12737/article_5a82e4a3908213.56647014
Кукушкин Ю.А., Солдатов С.К., Богомолов А.В., Шмакова Л.В. Определение вероятности возникновения первичных травм воздействии ударной волны // Безопасность жизнедеятельности. 2010. № 9 (117). С. 43-46.
Ничков С., Кривицкая Г.Н. Акустический стресс и церебро-висцеральные нарушения (морфо-физиологическое исследование). М: Медицина. 1969. 231 с.
Панкова В.Б. Значение количественной оценки потери слуха у лиц, работающих в условиях воздействия повышенной шумовой нагрузки // Вестник оториноларингологии. 2018. № 3. С. 33-36. https://doi.org/10.17116/otorino201883333
Сайфуллин Р.Ф., Гордиенко А.В., Литовский И.А., Селезнев А.Б. Изменение состава микробиоценоза кишечника экспериментальных животных в условиях низкочастотного шумового воздействия // Известия Российской Военно-медицинской академии. 2016. № 3. С. 39-44.
Уйба В.В., Котенко К.В., Степанов В.С. Биологическое действие инфразвука (гигиенические и медико-биологические аспекты) М.: ФМБЦ им. А.И.Бурназяна ФМБА России, 2012. 384 с.
Ушаков И.Б., Богомолов А.В. Диагностика функциональных состояний человека в приоритетных исследованиях отечественных физиологических школ // Медико-биологические и социально-психологические проблемы безопасности в чрезвычайных ситуациях. 2021. № 3. С. 91-100. https://doi.org/10.25016/2541-7487-2021-0-3-91-100
Ушаков И.Б., Богомолов А.В., Драган С.П., Солдатов С.К. Методологические основы персонифицированного гигиенического мониторинга // Авиакосмическая и экологическая медицина. 2017. Т. 51. № 6. С. 53-56.
Ушаков И.Б., Шафиркин А.В., Штемберг А.С. Физиология: реактивность и резистентность организма млекопитающих. М.: Юрайт, 2019. 471 с.
Шмидт-Ниельсен К. Размеры животных: почему они так важны? М.: Мир, 1987. 260 c.
Янов Ю.К., Кузнецов М.С., Глазников Л.А., Дворянчиков В.В., Сыроежкин Ф.А., Голованов А.Е., Гофман В.Р. Нарушения коркового отдела слухового анализатора при взрывной травме // Вестник оториноларингологии. 2022. Т. 87. № 1. С. 14-20. https://doi.org/10.17116/otorino20228701114
Berg S. J. P., Maltby L., Sinclair T., Liang R., Brink P. J. Cross-species extrapolation of chemical sensitivity // Science of the Total Environment, 2021, no. 753, p. 141800. https://doi.org/10.1016/j.scitotenv.2020.141800
Dragan S.P., Bogomolov A.V., Kotlyar-Shapirov A.D., Kondrat’eva E.A. A method for investigation of the acoustic reflex on the basis of impedance measurements // Biomedical Engineering, 2017, vol. 51, no. 1, pp. 72-76.
Dragan S.P., Kezik V.I., Bogomolov A.V., Drozdov S.V. Changes in lung volume caused by high-intensity acoustic oscillations at the resonant frequency of the respiratory system // Biophysics, 2023, vol. 68, no. 1, pp. 101-107. https://doi.org/10.1134/S0006350923010074
Iskhakova A.O., Alekhin M.D., Bogomolov A.V. Time-frequency transforms in analysis of non-stationary quasi-periodic biomedical signal patterns for acoustic anomaly detection // Information and Control Systems, 2020, no. 1 (104), pp. 15-23. https://doi.org/10.31799/1684-8853-2020-1-15-23
Lien S., Dickman J.D. Vestibular Injury After Low-Intensity Blast Exposure // Frontiers in Neurology, 2018, no. 9, p. 00297. https://doi.org/10.3389/fneur.2018.00297
Nesterenko V.F. Waves in strongly nonlinear discrete systems // Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2018, vol. 28, no. 376(2127), p. 20170130. https://doi.org/10.1098/rsta.2017.0130
Torija A.J., Li Z., Chaitanya P. Psychoacoustic modelling of rotor noise // Journal of the Acoustical Society of America, 2022, vol. 151, no. 3, p. 1804. https://doi.org/10.1121/10.0009801
Travis C.C. Interspecies extrapolation in risk analysis // Annali dell’Istituto Superiore di Sanità, 1991, vol. 27, no. 4, pp. 581-593.
Vasilyeva I., Bespalov V., Semenov A., Baranenko D., Zinkin V. The effects of low-frequency noise on rats: evidence of chromosomal aberrations in the bone marrow cells and the release of low-molecular-weight DNA in the blood plasma // Noise and Health, 2017, vol. 19, no. 87, pp. 79-83. https://doi.org/10.4103/nah.NAH-39-16
Vasilyeva I.N., Bespalov V.G., Zinkin V.N. Comparative analysis of harmful physical factors effect on the cell genome // Advances in Experimental Medicine and Biology, 2016, vol. 924, pp. 79-84.
Wiggins S.M., Krumpel A., Dorman L.M., Hildebrand J.A., Baumann-Pickering S. Seal bomb explosion sound source characterization // Journal of the Acoustical Society of America, 2021, vol. 150, no. 3, p. 1821. https://doi.org/10.1121/10.0006101
References
Akhmetzyanov I.M., Grebenkov S.V., Lomov O.P. Shum i infrazvuk. Gigienicheskie aspekty [Noise and infrasound. Hygienic aspects]. St. Petersburg: Bip, 2002, 100 p.
Bonitenko E.Yu., Kashuro V.A., Basharin V.A. Voprosy modelirovaniya v eksperimental’-noy toksikologii i meditsine. Biomodeli nulevogo poryadka [Modeling issues in experimental toxicology and medicine. Zero-order biomodels]. Meditsina truda i promysh-lennaya ekologiya [Occupational Medicine and Industrial Ecology], 2022, vol. 62. no. 11, pp. 718-732. https://doi.org/10.31089/1026-9428-2022-62-11-718-732
Gavrish N.N., Grabsky Yu.V., Pankratov V.V., Aminov A.M., Maksimov S.G., Kushchev G.G. A methodical approach to predicting the performance of specialist operators in extreme conditions of activity when using pharmacological means for correcting the functional state of the body, taking into account the extrapolation of data from animals to humans. Aviakosmicheskaya i ekologicheskaya meditsina [Aerospace and Ecological Medicine], 2016, vol. 50, no. 3, pp. 65-72.
Darenskaya N.G., Ushakov I.B., Ivanov I.V. Ekstrapolyatsiya eksperimental’nykh dannykh na cheloveka: printsipy, podkhody, obosnovanie metodov i ikh ispol’zovanie v fiziologii i radiobiologii [Extrapolation of experimental data on humans: principles, approaches, substantiation of methods and their use in physiology and radiobiology]. Moscow-Voronezh: Origins, 2004, 232 p.
Darenskaya N.G., Ushakov I.B., Ivanov I.V. Ot eksperimenta na zhivotnykh – k cheloveku: poiski i resheniya [From animal experiments to humans: searches and solutions]. Voronezh: Nauchnaya kniga, 2010, 237 p.
Dvoryanchikov V.V., Kuznetsov M.S., Logatkin S.M., Golovanov A.E. Evaluation of the impact of a special sound signal on the functional state of the hearing organ (experimental study). Meditsinskiy sovet [Medical Council], 2022, vol. 16, no. 20, pp. 16-21. https://doi.org/10.21518/2079-701X-2022-16-20-16-21
Dragan S.P., Bogomolov A.V. Method for assessing human acoustic safety. Siberian Journal of Life Sciences and Agriculture, 2021, vol. 13, no. 1, pp. 259-278. https://doi.org/10.12731/2658-6649-2021-13-1-259-278
Dragan S.P., Bogomolov A.V., Kezik V.I. Analysis of the impedance characteristics of the respiratory system of animals and humans. Rossiyskiy zhurnal biomekhaniki [Russian Journal of Biomechanics], 2020, vol. 24, no. 2, pp. 187-195. https://doi.org/10.15593/RZhBiomeh/2020.2.06
Dragan, S.P., Kezik, V.I., Bogomolov, A.V. Physiological aspects of lung impedansometry. Biology Bulletin, 2022, vol. 49, no 6, pp. 677-685. https://doi.org/10.1134/S106235902201006X
Zinkin V.N., Sheshegov P.M. Interference and masking effect of high-intensity noise and ways to reduce them. Aviakosmicheskaya i ekologicheskaya meditsina [Aerospace and environmental medicine], 2021, vol. 55, no. 6, pp. 5-12. https://doi.org/10.21687/0233-528X-2021-55-6-5-12
Ivanov I.V., Ushakov I.B. Basic approaches to extrapolation of data from animals to humans in a radiobiological experiment. Meditsinskaya radiologiya i radiatsionnaya bezopasnost’ [Medical Radiology and Radiation Safety], 2020, vol. 65, no. 3, pp. 5-12.
Ivanov N.I., Zinkin V.N., Slivina L.P. Biomechanical mechanisms of action of low-frequency acoustic vibrations on humans. Rossiyskiy zhurnal biomekhaniki [Russian Journal of Biomechanics], 2020, vol. 24, no. 2, pp. 216-231. https://doi.org/10.15593/RZhBiomeh/2020.2.09
Izmerov N.F., Suvorov G.A., Kuralesin N.A., Ovakimov V.G. Infrazvuk kak faktor riska zdorov’yu cheloveka (gigienicheskie, mediko-biologicheskie i patogeneticheskie mekhanizmy) [Infrasound as a risk factor for human health (hygienic, biomedical and pathogenetic mechanisms)]. Voronezh: Origins, 1998, 275 p.
Karkishchenko N.N. Through similarity and allometry criteria to validation and extrapolation in biomedicine. Biomeditsina [Biomedicine], 2007, no. 1, pp. 5-28.
Kovalenko I.Yu., Stepanov A.V., Seleznev A.B., Saifullin R.F., Ponomarev D.B. Pathogenetic substantiation of the formation of somatic pathology during prolonged exposure to low-frequency noise. Vestnik Rossiyskoy Voyenno-meditsinskoy akademii [Bulletin of the Russian Military Medical Academy], 2017, no. 2 (58), pp. 249-256.
Koterov A.N., Ushenkova L.N., Zubenkova E.S., Vainson A.A., Biryukov A.P. The ratio of the ages of the main laboratory animals (mice, rats, hamsters and dogs) and humans: relevance for the problem of age-related radiosensitivity and analysis of published data. Meditsinskaya radiologiya i radiatsionnaya bezopasnost’ [Medical Radiology and Radiation Safety], 2018, vol. 63, no. 1, pp. 5-27. https://doi.org/10.12737/article_5a82e4a3908213.56647014
Kukushkin Yu.A., Soldatov S.K., Bogomolov A.V., Shmakova L.V. Determination of the probability of occurrence of primary injuries under the influence of a shock wave. Bezopasnost’ zhiznedeyatel’nosti [Life Safety], 2010, no. 9 (117), pp. 43-46.
Nichkov S., Krivitskaya G.N. Akusticheskiy stress i tserebro-vistseral’nye narusheniya (morfo-fiziologicheskoe issledovanie) [Acoustic stress and cerebro-visceral disorders (morpho-physiological study)]. Moscow: Medicine, 1969, 231 p.
Pankova V.B. The value of quantitative assessment of hearing loss in persons working in conditions of exposure to increased noise load. Vestnik otorinolaringologii [Bulletin of Otorhinolaryngology], 2018, no. 3, pp. 33-36. https://doi.org/10.17116/otorino201883333
Saifullin R.F., Gordienko A.V., Litovsky I.A., Seleznev A.B. Changes in the composition of the intestinal microbiocenosis of experimental animals under conditions of low-frequency noise exposure. Izvestiya Rossiyskoy Voyenno-meditsinskoy akademii [Izvestiya of the Russian Military Medical Academy], 2016, no. 3, pp. 39-44.
Uiba V.V., Kotenko K.V., Stepanov V.S. Biologicheskoe deystvie infrazvuka (gigienicheskie i mediko-biologicheskie aspekty) [Biological effect of infrasound (hygienic and biomedical aspects)]. Moscow: Burnazyan Biophysical Center FMBA of Russia, 2012, 384 p.
Ushakov I.B., Bogomolov A.V. Diagnosis of human functional states in priority studies of domestic physiological schools. Mediko-biologicheskiye i sotsial’no-psikhologicheskiye problemy bezopasnosti v chrezvychaynykh situatsiyakh [Medico-biological and socio-psychological problems of safety in emergency situations], 2021, no. 3, pp. 91-100. https://doi.org/10.25016/2541-7487-2021-0-3-91-100
Ushakov I.B., Bogomolov A.V., Dragan S.P., Soldatov S.K. Methodological foundations of personalized hygienic monitoring. Aviakosmicheskaya i ekologicheskaya meditsina [Aerospace and environmental medicine], 2017, vol. 51, no. 6, pp. 53-56.
Ushakov I.B., Shafirkin A.V., Shtemberg A.S. Fiziologiya: reaktivnost’ i rezistent-nost’ organizma mlekopitayushchikh [Physiology: reactivity and resistance of the organism of mammals]. Moscow: Yurayt, 2019, 471 p.
Schmidt-Nielsen K. Razmery zhivotnykh: pochemu oni tak vazhny? [Animal sizes: why are they so important?]. Moscow: Mir, 1987, 260 p.
Yanov Yu.K., Kuznetsov M.S., Glaznikov L.A., Dvoryanchikov V.V., Syroezhkin F.A., Golovanov A.E., Gofman V.R. Violations of the cortical section of the auditory analyzer in case of explosive trauma. Vestnik otorinolaringologii [Bulletin of Otorhinolaryngology], 2022, vol. 87, no. 1, pp. 14-20. https://doi.org/10.17116/otorino20228701114
Berg S.J.P., Maltby L., Sinclair T., Liang R., Brink P. J. Cross-species extrapolation of chemical sensitivity. Science of the Total Environment, 2021, no. 753, p. 141800. https://doi.org/10.1016/j.scitotenv.2020.141800
Dragan S.P., Bogomolov A.V., Kotlyar-Shapirov A.D., Kondrat’eva E.A. A method for investiga-tion of the acoustic reflex on the basis of impedance measurements. Biomedical Engineering, 2017, vol. 51, no. 1, pp. 72-76.
Dragan S.P., Kezik V.I., Bogomolov A.V., Drozdov S.V. Changes in lung volume caused by high-intensity acoustic oscillations at the resonant frequency of the respiratory system. Biophysics, 2023, vol. 68, no. 1, pp. 101-107. https://doi.org/10.1134/S0006350923010074
Iskhakova A.O., Alekhin M.D., Bogomolov A.V. Time-frequency transforms in analysis of non-stationary quasi-periodic biomedical signal patterns for acoustic anomaly detection. Infor-mation and Control Systems, 2020, no. 1 (104), pp. 15-23. https://doi.org/10.31799/1684-8853-2020-1-15-23
Lien S., Dickman J.D. Vestibular Injury After Low-Intensity Blast Exposure. Frontiers in Neurol-ogy, 2018, no. 9, p. 00297. https://doi.org/10.3389/fneur.2018.00297
Nesterenko V.F. Waves in strongly nonlinear discrete systems. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2018, vol. 28, no. 376(2127), p. 20170130. https://doi.org/10.1098/rsta.2017.0130
Torija A.J., Li Z., Chaitanya P. Psychoacoustic modelling of rotor noise. Journal of the Acoustical Society of America, 2022, vol. 151, no. 3, p. 1804. https://doi.org/10.1121/10.0009801
Travis C.C. Interspecies extrapolation in risk analysis. Annali dell’Istituto Superiore di Sanità, 1991, vol. 27, no. 4, pp. 581-593.
Vasilyeva I., Bespalov V., Semenov A., Baranenko D., Zinkin V. The effects of low-frequency noise on rats: evidence of chromosomal aberrations in the bone marrow cells and the release of low-molecular-weight DNA in the blood plasma. Noise and Health, 2017, vol. 19, no. 87, pp. 79-83. https://doi.org/10.4103/nah.NAH-39-16
Vasilyeva I.N., Bespalov V.G., Zinkin V.N. Comparative analysis of harmful physical factors effect on the cell genome. Advances in Experimental Medicine and Biology, 2016, vol. 924, pp. 79-84.
Wiggins S.M., Krumpel A., Dorman L.M., Hildebrand J.A., Baumann-Pickering S. Seal bomb ex-plosion sound source characterization. Journal of the Acoustical Society of America, 2021, vol. 150, no. 3, p. 1821. https://doi.org/10.1121/10.0006101
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